AMPA receptors, ligand-gated ion channels that mediate fast, excitatory synaptic transmissions, are activated by glutamate, the primary neurotransmitter of the mammalian brain. Surprisingly ...

Spinal cord injury (SCI)—a condition that leads to partial or complete paralysis—has a profound impact on millions of ...

Spinal cord injury (SCI)-a condition that leads to partial or complete paralysis-has a profound impact on millions of individuals globally.

Inhibition of AMPA receptor endocytosis could help treat addiction to heroin. Van den Oever et al. have used a rat model to demonstrate that the link between re-exposure to preconditioned stimuli ...

The drug's action is linked to its ability to block NMDA receptors, reducing neuronal excitability. Additionally, ketamine's antidepressant effects may involve the activation of AMPA receptors and ...

In this study the authors showed that GSK3β is present in dendritic spines and is associated with AMPA (α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid) receptors, the trafficking of which ...

Perampanel is a non-competitive antagonist of the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on post-synaptic neurons. Glutamate is the primary ...

So far, we have identified several novel features related to functions and regulation of AMPA and kainate-type glutamate receptors at the developing synapses. Our current research aims to understand ...