Promising therapies for platinum-resistant ovarian cancer produced mixed results in separate trials. The AKT inhibitor ...

Network pharmacology and in vitro experiments reveal that Noscapine induces ROS-mediated apoptosis and cell cycle arrest via PI3K/Akt/FoxO3a signaling pathway in human bladder cancer cells.

Table 1 Current drugs in development that target the PI3K or related pathways Figure 1: Schematic of signalling through the phosphatidylinositol-3-kinase (PI3K)/AKT pathway. Class 1B PI3Ks consist ...