The research, published today in eLife, is described by editors as a fundamental study providing insights into how mutations in the presenilin-1 (PSEN1) gene affect processing of the amyloid precursor ...

A recent study published in eLife offers a new perspective on the development of Alzheimer’s disease, suggesting that the ...

A groundbreaking study reveals how a rare combination of genetics, proteomics, and environmental factors may hold the key to ...

Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s,” Charles Piller looks how the amyloid hypothesis took over ...

The investigational RNAi therapeutic targets mutant versions of amyloid precursor protein (APP), which are closely associated with familial cases of both Alzheimer’s and cerebral amyloid angiopathy.

A single injection of Alnylam’s RNA interference candidate ALN-APP – which is designed to switch off the production of amyloid precursor protein (APP) in the central nervous system – was ...

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy transthyretin moves hormones through blood and spinal fluid, misfolded ...

A research team has discovered that the two key pathological hallmarks of Alzheimer's -- tau protein and beta-amyloid -- affect brain circuits in distinct yet synergistic ways, particularly those ...

A new study showed that people who took longer to enter this dream phase of sleep had higher levels of amyloid beta and tau, ...

Increasing focus is now being placed on the production of Aβ – a process called proteolysis, during which a precursor protein called amyloid precursor protein (APP) is trimmed by an enzyme ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study. For several decades, researchers studying Alzheimer's disease have been working to ...