For the first time in over 10,000 years, the howl of a dire wolf is echoing once more—this time, from within a secretive nature preserve in the United States. The predator, long thought extinct and famously mythologized in pop culture like Game of Thrones, is back, thanks to genetic engineering.

Colossal Biosciences has successfully bred three dire wolf pups, named Remus, Romulus, and Khaleesi, using ancient DNA, cloning, and gene-editing tech

In a stunning scientific development, the prehistoric canines made famous in the hit HBO show have been announced as the world’s first de-extinct animal.