Some larger cargo, such as membrane proteins, nutrients, and pathogens, enter the cell via a process known as clathrin-mediated endocytosis. To gain a deeper understanding of this important ...

COPI also forms vesicles for intra-Golgi transport. Clathrin (blue) forms multiple complexes based on its association with different adaptor proteins (APs). Clathrin that is associated with AP1 ...

In our lab, we focus on clathrin-mediated endocytosis, the predominant route for membrane internalisation in most cells. In addition to its role in endocytosis, the clathrin machinery also forms ...

Clathrin-mediated endocytosis is a major endocytic route used by transferrin, growth-factor receptors and pathogenic viruses during infectious entry. Although clathrin-dependent uptake is the best ...