In preliminary studies, the DIfE team headed by PD Dr. Heike Vogel used transcriptome analyses to identify phosphatidylinositol binding clathrin assembly protein (PICALM) as one of the genes with ...

For example, to "eat," cells rely on hexagonal supramolecular networks that self-assemble from units of the three-armed protein clathrin. Clathrin networks form bubbles around nutrients to bring ...

Clathrin-mediated endocytosis is a major endocytic route used by transferrin, growth-factor receptors and pathogenic viruses during infectious entry. Although clathrin-dependent uptake is the best ...

COPI also forms vesicles for intra-Golgi transport. Clathrin (blue) forms multiple complexes based on its association with different adaptor proteins (APs). Clathrin that is associated with AP1 ...

In our lab, we focus on clathrin-mediated endocytosis, the predominant route for membrane internalisation in most cells. In addition to its role in endocytosis, the clathrin machinery also forms ...