When investigating NSAID inhibition of COX in vitro some important considerations are the source of the enzyme, the Michaelis constant (K m) of the endogenous substrate arachidonic acid ...

A novel PET imaging approach can effectively quantify a key enzyme associated with brain inflammation, according to research published in the March issue of The Journal of Nuclear Medicine.

The first-in-human study, which imaged the COX-2 enzyme, offers a never-before-seen view of inflammation in the brain, opening the door for COX-2 PET imaging to be used in clinical and research ...