Important considerations when investigating NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous substrate arachidonic acid, the mechanism of ...

The first-in-human study, which imaged the COX-2 enzyme, offers a never-before-seen view of inflammation in the brain, opening the door for COX-2 PET imaging to be used in clinical and research ...

A novel PET imaging method, using the radiotracer 11C-MC1, successfully quantifies COX-2 enzyme levels in the human brain. This technique opens the door for earlier detection, monitoring of disease ...