The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would help forecast the half-life of the antibody, while that between the Fc fragment and FcγRIIIa (CD16a) would impact the ...

VRDN-006 is a highly selective Fc fragment which inhibits FcRn and is designed to be a convenient subcutaneous and self-administered option for patients. Proof-of-Concept Phase 1 Clinical Data On ...

The stem portion confers additional functions to antibodies, including fixing complement and activating immune cells by binding to crystallizable fragment (Fc) receptors. Finally, fragment modes ...