The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would help forecast the half-life of the antibody, while that between the Fc fragment and FcγRIIIa (CD16a) would impact the ...

VRDN-006 is a highly selective Fc fragment which inhibits FcRn and is designed to be a convenient subcutaneous and self-administered option for patients. Proof-of-Concept Phase 1 Clinical Data On ...

The stem portion confers additional functions to antibodies, including fixing complement and activating immune cells by binding to crystallizable fragment (Fc) receptors. Finally, fragment modes ...

Tonix Pharmaceuticals has reported positive topline outcomes from its Phase I single ascending dose study of its crystallisable fragment (Fc)-modified humanised anti-CD40 ligand (CD40L ...