Thus, candidates should be tested against a panel of receptors at the time of antibody engineering. ACROBiosystems provides an extensive collection of recombinant Fc receptor proteins, which ...

Previous studies established defective Fc receptor mediated clearance in patients with systemic lupus erythematosis (SLE), a disorder associated with circulating immune complexes (CIC).

The Dutch biotech company said the product was the first and only neonatal Fc receptor blocker approved to treat the condition. The product is co-formulated with Halozyme Therapeutics’ (HALO ...

Fc-gamma receptors (FcγRs) are a group of cell surface proteins found on a range of immune cells. These proteins represent the primary cell signaling method between IgG antibodies and our immune ...

The FDA has granted fast-track designation to nipocalimab for the treatment of Sjögren’s disease, according to a press ...

FDA grants Fast Track designation to Johnson & Johnson’s investigational therapy nipocalimab for the treatment of moderate-to ...

Published in the peer-reviewed journal mAbs, the study presents nipocalimab's high-affinity binding to the neonatal Fc receptor (FcRn) and its capability to significantly reduce IgG levels ...

Opens in a new tab or window Recently approved treatments for generalized myasthenia gravis (gMG), including complement and neonatal Fc receptor (FcRn) inhibitors, offer a new treatment paradigm ...

Concentration-dependent cleavage of IgE B cell receptor. Concentration-dependent reduction of expression of the high-affinity IgE Fc receptor, on bone marrow-derived mast cells from humanized mice.