Single-cell analysis revealed the molecular triggers that drive stem cells to become cancerous, which may help inform ...
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Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and diseaseThe HIPPO pathway controls organ size by regulating cell proliferation and apoptosis, acting through its core components MST1/2, LATS1/2, and downstream effectors YAP and TAZ. In the liver ...
S-969, a first-in-class small molecule targeting a key kinase on the Hippo-YAP axis, has demonstrated promising potential in addressing debilitating conditions such as Duchenne muscular dystrophy ...
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