Janus kinase inhibitors (JAKis) are an important treatment option for people with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, Crohn's disease or ulcerative colitis. Since ...

We previously showed that t(8;21) fusion protein acute myeloid leukemia (AML)1–ETO and its alternatively spliced variant AML1–ETO9a (AE9a) enhance the JAK/STAT pathway via downregulation of ...

The Janus kinase 2 (JAK2) protein mediates signaling from several cytokine receptors in the regulation of hematopoiesis and immune responses. Somatic mutations in human JAK2 lead to constitutive ...