LDL receptor activity and uptake of LDL regulate plasma LDL concentration by several mechanisms, including decreasing the synthesis of hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase (which ...

Familial hypercholesterolemia results from gene mutations approximately halving the number of functional LDL receptors in heterozygotes and a greater lack in homozygotes. Reduced receptor-mediated ...

A cholesterol receptor protein called LDLR appears to be a key driver of neurotoxicity in sporadic ALS, per new research ...