To examine how changes in these pathways affect ISCs, the researchers treated intestinal organoids with IFN-γ and iMEK (an inhibitor of MEK/ERK MAPK signaling). Notably, iMEK induced a quiescent ...
The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...
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