In particular, the activities of two MAPK, p38MAPK and MEK/ERK, were upregulated. In ME, p38MAPK signaling increases the activity of transporter proteins that pump out drugs from cells.

To examine how changes in these pathways affect ISCs, the researchers treated intestinal organoids with IFN-γ and iMEK (an inhibitor of MEK/ERK MAPK signaling). Notably, iMEK induced a quiescent ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...

a downstream target of Ras in the Raf/MEK/ERK pathway — was unaffected. However, expression of mutant SOCS-3, while continuing to inhibit STAT5 activation, severely abrogated ERK activity.