Immune cell trapping during allergic responses Mast cells, residing in tissues and critical for initiating inflammation, are filled with granules containing pro-inflammatory substances. These ...

It stems from having too many mast cells in the skin, a type of white blood cell involved in the immune system. Understanding ...

At the recent AAAAI/WAO meeting, Blueprint Medicines Corp. presented the in vitro and in vivo characterization of BLU-808, a selective inhibitor of wild-type KIT, a transmembrane receptor tyrosine ...

Caroline Cray was diagnosed with mast cell activation syndrome in May 2019 after repeated anaphylactic episodes Jordan Greene is Society and Culture writer-reporter at PEOPLE. She has been working ...

BLU-808 achieved dose-dependent serum tryptase reductions exceeding 80 percent, reflecting evidence of mast cell target engagement. BLU-808 had a half-life supporting once-daily oral dosing and ...

No objections were raised, and planners said the mast must be erected in the next ... whilst still being located in the cell area in a way that it can replicate the coverage footprint of the ...

Type I allergy, an IgE antibody triggered hypersensitivity disease, represents a common public health problem affecting about one third of the world´s population. Upon exposure to allergens, IgE ...