When miRNA acts as the guide for RNAi ... Additionally, siRNAs induce gene silencing by guiding histone and DNA methylation, which inactivates chromatin and represses transcription. 1 Scientists have ...

Various gene silencing technologies like siRNA, miRNA, ribozymes, DNAzymes have shown promise as therapeutics agents against viral diseases. RNAi-based drugs against viruses such as ebola virus ...

To the Editor: microRNAs (miRNAs) are short RNAs that are important in gene regulation in many organisms. In mammals, they guide the RNA-induced silencing ... validation of miRNA targets remains ...

This is unwound and loaded onto the RNA-induced silencing complex (RISC ... This occurs as part of a combined protein/miRNA gene expression program and there may be some unique properties that ...

RNAi is widely used to study gene function by selectively silencing specific genes and observing the resulting ... By designing siRNAs or miRNA mimics that target disease-associated genes, researchers ...

A strong focus of our lab is the computational analysis of post-transcriptional gene regulation, in particular microRNA-mediated gene regulation. We introduced the mirSVR target prediction method, ...