When miRNA acts as the guide for RNAi ... Additionally, siRNAs induce gene silencing by guiding histone and DNA methylation, which inactivates chromatin and represses transcription. 1 Scientists have ...

To the Editor: microRNAs (miRNAs) are short RNAs that are important in gene regulation in many organisms. In mammals, they guide the RNA-induced silencing ... validation of miRNA targets remains ...

which target a single gene for silencing, miRNAs can target hundreds of genes. “An amazing new application of miRNA tools uses viral vectors,” says Leake. For researchers interested in the ...

InteRNA is focusing on the development of gene-silencing drugs based on microRNA, naturally occurring, non-coding strands of RNA that are thought to regulate gene expression in cells. MicroRNAs ...

RNAi is widely used to study gene function by selectively silencing specific genes and observing the resulting ... By designing siRNAs or miRNA mimics that target disease-associated genes, researchers ...

A strong focus of our lab is the computational analysis of post-transcriptional gene regulation, in particular microRNA-mediated gene regulation. We introduced the mirSVR target prediction method, ...