Researchers at Osaka University conducted the study using primary human foreskin fibroblasts (HFF-1 cells), which were ...

From a broader perspective, it will be imperative to find out why cytokine signalling promotes replicative and oncogene-induced senescence, but does not seem to induce senescence in every ...

We want to know, for example, does a keratinocyte undergoing replicative senescence secrete a similar type of inflammatory molecule as a fibroblast undergoing senescence induced by ultraviolet ...

At this point, DNA repair systems recognize it as DNA damage and trigger a form of permanent cell cycle arrest called replicative senescence, which may lead to cell death called apoptosis. 5 This ...