In the context of SUDs, although there are no direct studies on astrocytic mGLUR5, evidence from related research suggests that it may be involved in regulating cue-associated drug memories.

Recently, several pharmaceutical companies have begun to develop and test new, highly specific and potent drugs that antagonize mGluR5 signaling for the treatment of epilepsy and FXS, and these ...

That would be an important advance to complement ongoing work Bear's lab has done to correct fragile X protein synthesis levels via another receptor called mGluR5. In the new study, Bear and ...

For a long time, neuroscience research on drug addiction mainly focused on neuronal mechanisms ... and metabotropic glutamate receptor 5 (mGLUR5). These receptors respond to various ligands, ...