In addition to cell-cycle regulation, mTOR plays a role in muscle hypertrophy following increased use through the growth factor IGF-1 and tumor suppressor PTEN. Blocking mTOR with drugs like rapamycin ...

Single-cell analysis revealed the molecular triggers that drive stem cells to become cancerous, which may help inform ...

Researchers from SRM Institute of Science and Technology, led by Dr. KN Aruljothi, have published a study in ExRNA ...

Using breast cancer patient-derived organoids and tumor ... Key changes include reduced activity of mTOR, a metabolic ...

A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

It examines the impact of mTOR on podocytes, glomerular mesangial cells, renal tubular epithelial cells, and glomerular endothelial cells—each playing a crucial role in kidney function.

Adding metformin to letrozole and abemaciclib (Verzenio) was tied to deep responses and prolonged progression-free survival ...

Everolimus (Afinitor) is a drug that blocks the mTOR protein and helps stop the growth and spread of cancer cells. PI3K inhibitors. Alpelisib (Piqray) and inavolisib (Itovebi) block a type of ...

Scientists at Southern University of Science and Technology in Shenzhen, China, have identified a new regulator of the mammalian target of rapamycin (mTOR) pathway associated with the growth of ...