Dicer also processes ... Only one strand of the miRNA:miRNA* duplex or the siRNA duplex is preferentially assembled into the RNA-induced silencing complex (RISC) , which subsequently acts on ...

First discovered by the laboratories of Victor Ambros and Gary Ruvkun in Caenorhabditis elegans, microRNAs (miRNAs) are the first extensively studied class of noncoding RNA. 1, 2 There are between ...

Elucidation of molecular mechanisms of viral replication and signal transduction pathways involved in viral pathogenesis, have opened new avenues for the development of alternative therapeutic ...

View Full Profile. Learn about our Editorial Policies. The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi ...

miRNAs are transcribed as long primary miRNAs (pri-miRNAs), which are processed by the enzymes Drosha and Dicer to generate mature miRNAs ... By designing siRNAs or miRNA mimics that target ...