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Gut12d
Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression
Background Development of diffuse-type gastric cancer (DGC) starts with intramucosal lesions that are primarily composed of ...
gut.bmj3d
Perspective on enhancing CRC risk prediction
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gut.bmj11d
Response to: correspondence on 'Revisiting the role of sphincterotomy in sphincter of Oddi disorder: a critical appraisal of the RESPOnD study by Zeng
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gut.bmj1d
Guidelines for the management of iron deficiency anaemia
Correspondence to Brian B Scott, Department of Medicine, Lincoln County Hospital, Lincoln LN2 5QY, UK; drbbscott{at}aol.com Iron deficiency anaemia (IDA) occurs in 2–5% of adult men and postmenopausal ...
gut.bmj8d
Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis
Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and ...
gut.bmj3d
Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma
Objective To characterise gut microbiome in patients with hepatocellular carcinoma (HCC) and evaluate the potential of microbiome as non-invasive biomarkers for HCC. Design We collected 486 faecal ...
gut.bmj5d
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing
Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...
gut.bmj4d
Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts
Objective We aimed to determine the predictive capacity and diagnostic yield of a 10-fold increase in serum IgA antitissue transglutaminase (tTG) antibody levels for detecting small intestinal injury ...
gut.bmj8d
TPX2 serves as a novel target for expanding the utility of PARPi in pancreatic cancer through conferring synthetic lethality
Background PARP inhibitors (PARPi) have been licensed for the maintenance therapy of patients with metastatic pancreatic cancer carrying pathogenic germline BRCA1/2 mutations. However, mutations in ...
gut.bmj8d
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Correspondence to Professor Alfred Sze-Lok Cheng, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; alfredcheng{at}cuhk.edu.hk; Professor Joseph Jao-Yiu Sung, Lee ...
gut.bmj5d
Environmental impact of single-use versus reusable gastroscopes
Introduction The environmental impact of endoscopy is a topic of growing interest. This study aimed to compare the carbon footprint of performing an esogastroduodenoscopy (EGD) with a reusable (RU) or ...
gut.bmj4d
Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity
Correspondence to Dr Giovanni Barbara, Department of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy; giovanni.barbara{at}unibo.it Objective Non-coeliac gluten sensitivity ...