Subsequent experiments demonstrated that NEU1 knockdown reduced lipid accumulation through promoting perilipin 2 (PLIN2)-mediated lipophagy. Notably, OP (NEU1 inhibitor), promoted lipophagy, thereby ...

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. (Y.X., X.-Y.W., Z.-Y.H., H.Z., Z.-Y.Y ...

E3 ubiquitin (Ub) ligases play crucial roles in diverse cellular processes and their activity is strictly regulated. HECT-type E3 Itch is activated and recruited to lipid droplets by Spartin to ...