Memantine - ALZFORUM
Oct 9, 2023 · Memantine was studied unsuccessfully for neuropathic pain and diabetic neuropathy (Rogers et al., 2009, Sang et al., 2002). At least one early clinical trial of memantine in patients with vascular dementia appears to have shown cognitive improvement, but no further studies on this indication have been reported in the past 10 years ( Wilcock et ...
Memantine—Good for a Year, But Little Disease Modification
Jan 16, 2018 · Memantine Relieves Symptoms in Moderate to Severe AD 9 Apr 2003; Memantine Wins FDA Approval 21 Oct 2003; Paper Citations. Leber P. Slowing the progression of Alzheimer disease: methodologic issues. Alzheimer Dis Assoc Disord. 1997;11 Suppl 5:S10-21; discussion S37-9. PubMed. Further Reading
Masupirdine - ALZFORUM
Feb 8, 2023 · The trial compared 26 weeks of treatment with 50 or 100 mg of SUVN-502 daily to placebo, all given in addition to donepezil and memantine. Conducted at 57 sites in the United States, this trial measured change on the ADAS-Cog11 as primary, and change on the CDR and various clinical and functional scales as secondary outcomes.
HMTM | ALZFORUM
May 10, 2024 · The trial compares a six-month course of 4 mg of LMTM—renamed to HMTM—twice daily. This is the daily dose of HMTM previously admixed to "active placebo'' in the prior Phase 3 trials. LMTM is compared to 4 mg Methylene Blue twice weekly. Acetylcholinesterase inhibitors or memantine are not allowed.
Memantine Strikes Out in Down's Syndrome - ALZFORUM
Jan 13, 2012 · Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome. J Alzheimers Dis. 2010;21(1):277-90. PubMed. Lockrow J, Boger H, Bimonte-Nelson H, Granholm AC. Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome. Behav Brain …
RG3487 - ALZFORUM
Oct 25, 2023 · Also in 2010, Roche conducted an open-label phase 1 study in 16 healthy adults to evaluate the effect of memantine on the pharmacokinetics, safety and tolerability of RO5313534 and vice versa. Development of this drug has been discontinued. For details on clinical trials on this compound, see clincialtrials.gov. Last Updated: 25 Oct 2023. Comments
Memantine Wins FDA Approval | ALZFORUM
Nov 19, 2003 · I plan to review results of long-term use of memantine in Germany, where I believe it has been used for some years, to see if there has been much success in its use. There has been a lot of emphasis on early diagnosis of Alzheimer's disease with the expectation that early intervention could provide a better chance in averting or even preventing ...
Aducanumab Approved to Treat Alzheimer’s Disease - ALZFORUM
Jun 8, 2021 · Reactions among Alzheimer’s researchers spanned the gamut. Some were enthusiastic. Jeffrey Cummings at the University of Nevada, Las Vegas, wrote, “The FDA has taken a courageous stand to approve a drug when there were many loud—and often well-reasoned—voices to the contrary …
Compounding and Characterization of Oral Disintegrating Films ...
Compounding and Characterization of Oral Disintegrating Films Containing Memantine Hydrochloride for Geriatrics. Int J Pharm Compd . 2023;27(6):512-521. PubMed .
Memantine in moderate-to-severe Alzheimer's disease. - ALZFORUM
May 14, 2003 · The correct approach to the problem is at a primary level, by correcting the lipid peroxidation with vitamin E, a measure which renders memantine trials completely unnecessary. Long-chain n-3 EFA are also recommended, to replace the marked oxidative loss of these vital synaptic membrane lipids seen in moderate to advanced disease.