HIV immune evasin Nef enhances allogeneic CAR T cell potency | Nature
Jan 30, 2025 · Autologous chimeric antigen receptor (CAR) T cells are a genetically engineered therapy that is highly effective against B cell malignancies and multiple myeloma 1. However, the length and...
Deep learning enhances the prediction of HLA class I-presented CD8 - Nature
Jan 28, 2025 · Nature Machine Intelligence - Accurate prediction of immunogenic CD8+ T cell epitopes would greatly accelerate T cell vaccine development. A new deep learning model, MUNIS, can rapidly...
Neuropeptide signalling orchestrates T cell differentiation | Nature
Oct 16, 2024 · We identified regulators modulating T helper cell differentiation using a unique T H 1–T H 2 cell dichotomous culture system and systematically validated their regulatory functions through...
Enhancing T cell therapy - Nature Immunology
Mar 3, 2025 · Data now published in Cell Metabolism show that these culture systems result in T cells that are not optimal for killing tumors. The researchers compared in vitro and in vivo expansion of OT-I...
Low-avidity T cells drive endogenous tumor immunity in mice ... - Nature
Jan 9, 2025 · Here, we analyze neoepitope-specific CD8 cells of distinct avidities and show that low-avidity T cells are the sole mediators of cancer control in mice and are solely responsive to checkpoint...
Nutrient metabolism shapes epigenetic landscape of T cells | Nature ...
Jan 31, 2025 · CD8 + T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to understand for the generation of immunotherapies to treat cancer. Research now shows how...
Nature
3 days ago · First published in 1869, Nature is the world’s leading multidisciplinary science journal. Nature publishes the finest peer-reviewed research that drives ground-breaking discovery, and is...
Prohormone cleavage prediction uncovers a non-incretin anti ... - Nature
Mar 5, 2025 · Peptide hormones, a class of pharmacologically active molecules, have a critical role in regulating energy homeostasis. Prohormone convertase 1/3 (also known as PCSK1/3) represents a key enzymatic ...
Redirecting immune signaling with cytokine adaptors - Nature
4 days ago · Cytokines are immune signaling molecules that are frequently dysregulated in disease. Here, the authors create engineered cytokine ‘adaptors,’ molecular switches that simultaneously block a ...
Highly multiplexed imaging in the omics era: understanding ... - Nature
Dec 6, 2024 · Through the analysis of large human tissue collections, spatial proteomics will reveal the complexities of human tissues and uncover multicellular modules that can serve as drug targets and...